NMSEZ has inherent locational advantages on account of its proximity to Mumbai - India's financial and commercial capital. The SEZ has access to well-developed road and rail linkages as well as one of India's largest and most modern seaport - Jawaharlal Nehru Port Trust (JNPT). The zone is also located in close proximity to other large industrial areas, providing access to several feeder industries. Further, its location on the Pune-Mumbai-Thane knowledge corridor provides it with instant access to skilled manpower in the region.

Dronagiri

The Dronagiri zone is located at the southern tip of Navi Mumbai. The site is located to the east of Uran town, and is bound by the Karanja Creek on the south-east. Residential areas are located to the west and north-west of the zone, while the JNPT port area and township are located towards the north of the zone. The zone is adjacent to the JNPT port, and is located farthest from the central business districts of Belapur, Nerul and Vashi. Due to its proximity to the port, this zone would support apparels, light engineering and logistics. Also due to large residential area in its vicinity, IT / ITES activity would also be attracted.

Kalamboli

The Kalamboli zone lies on the eastern tip of Navi Mumbai and adjoins the Taloja MIDC area. The zone is easily accessible by road from Thane, Ambernath, Taloja and the rest of Navi Mumbai. The Diva-Panvel railway line (Konkan Railway) touches the periphery of the zone. Further, the zone is located at a distance of one kilometer from the National Highway (NH-4) and the Mumbai-Pune Expressway and is connected to these highways by a eight-lane road. The zone is also in close proximity to the suburban railway line connecting Mumbai to Panvel. When compared to the Dronagiri zone, the Kalamboli zone is closer to CBD Belapur. Due to its excellent linkages with other areas, the zone is ideal for financial services / IT / ITES activity.

Ulwe

The Ulwe zone is situated along the south- western waterfront of the Central Business District of Navi Mumbai and extends towards the new Nhava Shava Docks (JNPT) to south. The proposed rail link between Belapur and Uran also passes through the zone. In addition, the zone is adjacent to the proposed water terminals, and is closest to south Mumbai in terms of travel times. The proposed second international airport for Mumbai is located near Ulwe.

Due to the zone's proximity to residential areas, lower commuting time from Mumbai and the proposed new international airport, this zone is best suited for service industries like financial services, IT, biotech, diamonds, jems, jewellery, airport related activities, etc.